Cover Picture: Tools for Glycomics: Mapping Interactions of Carbohydrates in Biological Systems (ChemBioChem 10/2004)

Cover Picture: Detection of mRNA in Mammalian Cells with a Split Ribozyme Reporter (ChemBioChem 6/2006)

The cover picture shows a split RNA reporter strategy for detecting target mRNA in mammalian cells. A tetrahymena group I intron ribozyme reporter is split into two halves, each of which carries a part of the coding sequence of the reporter mRNA, a fragment of the ribozyme, and an antisense sequence complementary to a target mRNA. Both halves bind with the target mRNA and are assembled into an ...

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Collaboratative Mapping and Analysis Tools for Biological Spatio-Temporal Databases

The purpose of this project is to deliver fast and collaborative image processing to the biology laboratory bench. This will be achieved in the context of spatial data mapping, reconstruction, analysis and database query by developing GRID-enabled tools based on the existing tools developed as part of the Mouse Atlas Program at the MRC Human Genetics Unit. The Mouse Atlas Program at the MRC Hum...

Cooperativity in biological systems

Living organisms can sense and respond to external and internal stimuli. Response isdemonstrated in many forms including modulation of gene expression profiles, motility,secretion, cell death, etc. Nevertheless, all forms share a basic property: they depend on sensingsmall changes in the concentration of an effector molecule or subtle conformational changes ina protein and invoking the appropri...

Cover Picture: Reversible Mechanical Switching of Magnetic Interactions in a Molecular Shuttle (ChemistryOpen 1/2015)

Full Paper: Tetra-substituted thiophene inhibitors of p38a MAPK (P. J. Scammells)